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ea0034p286 | Pituitary | SFEBES2014

The gonadotroph natriuretic peptide system is sensitive to pulsatile GnRH stimulation: insights into CNP/GC-B signalling in gonadotroph function

Mirczuk Samantha , Catterick Alice , Lessey Andrew , Perrett Rebecca , McArdle Craig , McGonnell Imelda , Fowkes Robert

Gonadotrophs in rats, mice and humans, express an intact natriuretic peptide system, in which C-type natriuretic peptide (CNP) is the predominant member. Despite showing an interaction between CNP and GnRH at the level of cGMP and Ca2+ signalling, the role of CNP in gonadotroph biology is poorly understood. In this study, we utilise a novel multiplex qRT-PCR assay, examining simultaneous expression of natriuretic peptide genes along with genes for gonadotroph transc...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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